Benzylic oxidation catalyzed by dirhodium(II,III) caprolactamate

被引：201

作者：

Catino, AJ ^{[1
]}

Nichols, JM ^{[1
]}

Choi, H ^{[1
]}

Gottipamula, S ^{[1
]}

Doyle, MP ^{[1
]}

机构：

[1] Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 23期

关键词：

D O I：

10.1021/ol0520020

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Dirhodium caprolactamate [Rh-2(cap)(4)] is an effective catalyst for benzylic oxidation with tert-butyl hydroperoxide (TBHP) under mild conditions. Sodium bicarbonate is the optimal base additive for substrate conversion. Benzylic carbonyl compounds are readily obtained, and a formal synthesis of palmarumycin CP2 using this methodology is described.

引用

页码：5167 / 5170

页数：4

共 37 条

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