Molecular biology and pharmacology of galanin receptors

被引：88

作者：

Branchek, T ^{[1
]}

Smith, KE ^{[1
]}

Walker, MW ^{[1
]}

机构：

[1] Synapt Pharmaceut Corp, Paramus, NJ 07652 USA

来源：

GALANIN: BASIC RESEARCH DISCOVERIES AND THERAPEUTIC IMPLICATIONS | 1998年 / 863卷

关键词：

D O I：

10.1111/j.1749-6632.1998.tb10687.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Galanin was first isolated 15 years ago. Diversity of galanin receptors has been suspected from the study of native tissues and functional responses to galanin and galanin-like peptides in vitro and in vivo. The recent application of molecular biologic techniques to clone galanin receptors has extended this diversity. So far, three galanin receptor subtypes, GALR1, GALR2, and GALR3, have been cloned from both human and rat. Their molecular structure, pharmacologic profiles, tissue distribution, and signal transduction properties have been partially elucidated.

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页码：94 / 107

页数：14

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