Etiology of gastric cancer: What is new?

被引：37

作者：

Correa, P

Schneider, BG

机构：

[1] Louisiana State Univ, Hlth Sci Ctr, Dept Pathol, New Orleans, LA 70112 USA

[2] Stanley Scott Canc Ctr, New Orleans, LA USA

来源：

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION | 2005年 / 14卷 / 08期

关键词：

D O I：

10.1158/1055-9965.EPI-05-0029

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Recent advances in understanding of risk factors for gastric cancer have focused attention on genetic polymorphisms in both the human host and in Helicobacter pylori. Variation in genes for cytokines such as interleukin-1 beta and its receptor antagonist may allow identification of those individuals predisposed to mount an immune response that puts them at elevated risk for gastric cancer. Likewise, analysis of how genetic variation in the genome of H. pylori may modulate the action of virulence factors like CagA may prove useful in identification of persons for whom H. pylori eradication efforts would be most important. This review examines recent studies on interleukin-1 beta polymorphisms and H. pylori CagA variation with respect to their modulation of risk for gastric cancer.

引用

页码：1865 / 1868

页数：4

共 54 条

[51] ANALYSIS OF EXPRESSION OF CAGA AND VACA VIRULENCE FACTORS IN 43 STRAINS OF HELICOBACTER-PYLORI REVEALS THAT CLINICAL ISOLATES CAN BE DIVIDED INTO 2 MAJOR TYPES AND THAT CAGA IS NOT NECESSARY FOR EXPRESSION OF THE VACUOLATING CYTOTOXIN [J].