Collagen cross-links:: a convenient synthesis of tert-butyl-(2S)-2-[(tert-butoxycarbonyl)amino]-4-(2-oxiranyl)butanoate

被引：37

作者：

Adamczyk, M ^{[1
]}

Johnson, DD ^{[1
]}

Reddy, RE ^{[1
]}

机构：

[1] Abbott Labs, Div Diagnost, Div Organ Chem Res, Abbott Pk, IL 60064 USA

来源：

TETRAHEDRON-ASYMMETRY | 1999年 / 10卷 / 04期

关键词：

D O I：

10.1016/S0957-4166(99)00055-5

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

An efficient synthesis of tert-butyl-(2S)-2-[(tert-butoxycarbonyl)amino]-4-(2-oxiranyl)butanoate (5), the key intermediate for preparation of collagen cross-links (+)-pyridinoline (Pyd, 1) and (+)-deoxypyridinoline (Dpd, 2) was described from (4S)-5-(tert-butoxy)-4-[(tert-butoxycarbonyl)amino]-5-oxopentanoic acid (6) in six steps. Also, an improved synthesis of iodide (2S)-(-)-4b was presented. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：775 / 781

页数：7

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