Role of adipose tissue for cardiovascular-renal regulation health and disease

被引：82

作者：

Engeli, S ^{[1
]}

Sharma, AM ^{[1
]}

机构：

[1] Humbolt Univ Berlin Klinikum, Charite, Max Delbruck Ctr Mol Med, Franz Volhard Klin,Dept Nephrol & Hypertens, D-13125 Berlin, Germany

来源：

HORMONE AND METABOLIC RESEARCH | 2000年 / 32卷 / 11-12期

关键词：

fat cells; obesity; hypertension; renin-angiotensin system; non-esterified fatty acids; leptin; nitric oxide; atrial natriuretic peptide; prostacyclin; adipose tissue blood flow;

D O I：

10.1055/s-2007-978675

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Obesity is associated with profound alterations of the cardiovascular system including an increase in systemic blood pressure. Several vasoactive factors, including non-esterified fatty acids, angiotensin II, prostaglandins, and nitric oxide are known to be produced by adipose tissue, and are therefore of particular interest regarding their potential role for the regulation of vascular tone and structure. In addition, central nervous system actions of the adipose tissue-derived hormone leptin may contribute to increased sympathetic nervous system activity that is typically found in obesity. Enhanced leptin-driven renal sympathetic out-flow, in combination with low atrial natriuretic peptide plasma levels possibly due to over-expression of the natriuretic peptide clearance receptor in adipocytes, may enhance sodium retention and volume expansion, both key features in the pathophysiology of obesity-associated hypertension. In this review, we discuss these and other possible contributions of adipose tissue to the regulation of cardiovascular-renal function and speculate on the role of adipose tissue for the development of obesity-associated hypertension.

引用

页码：485 / 499

页数：15

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