OBJECTIVE. This article identifies the most commonly encountered issues of combined PET/CT and shows the wide variability in perceived possible solutions to these issues. This article will serve as a catalyst to stimulate discussion between experts in both radiology and nuclear medicine. CONCLUSION. Combining a PET tomography and CT scanner into a single unit amounts to advantages that are not merely additive, but synergistic. Even PET/CT skeptics will embrace the technology after becoming acquainted with the possibilities and will accept the reality that there is no return to PET only.