Mitochondrial permeability transition pore (MPTP)-dependent and -independent pathways of mitochondrial membrane depolarization, cell shrinkage and microparticle formation during platelet apoptosis

被引:37
作者
Gyulkhandanyan, Armen V. [1 ,2 ]
Mutlu, Asuman [1 ,2 ]
Freedman, John [1 ,3 ,4 ]
Leytin, Valery [1 ,2 ,5 ]
机构
[1] St Michaels Hosp, Toronto Platelet Immunobiol Grp, Toronto, ON M5B 1W8, Canada
[2] St Michaels Hosp, Keenan Res Ctr Biomed Sci, Toronto, ON M5B 1W8, Canada
[3] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada
[4] Univ Toronto, Dept Med, Toronto, ON, Canada
[5] Ryerson Univ, Dept Phys, Toronto, ON, Canada
关键词
platelets; apoptosis; mitochondria; permeabilization; depolarization; ACTIVATION; INHIBITOR; ABT-737; DEATH;
D O I
10.1111/bjh.13180
中图分类号
R5 [内科学];
学科分类号
100201 [内科学];
摘要
引用
收藏
页码:142 / 145
页数:4
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