Reciprocal Activation of Prostate Cancer Cells and Cancer-Associated Fibroblasts Stimulates Epithelial-Mesenchymal Transition and Cancer Stemness

被引：459

作者：

Giannoni, Elisa ^{[3
,4
]}

Bianchini, Francesca ^{[1
]}

Masieri, Lorenzo ^{[2
]}

Serni, Sergio ^{[2
]}

Torre, Eugenio ^{[1
]}

Calorini, Lido ^{[1
]}

Chiarugi, Paola ^{[3
,4
]}

机构：

[1] Univ Florence, Dept Expt Pathol & Oncol, I-50134 Florence, Italy

[2] Univ Florence, Dept Urol, I-50134 Florence, Italy

[3] Univ Florence, Dept Biochem Sci, Tuscany Tumor Inst, Florence, Italy

[4] Ctr Res Transfer & High Educ DenoTHE, Florence, Italy

来源：

CANCER RESEARCH | 2010年 / 70卷 / 17期

关键词：

TUMOR PROGRESSION; GENOMIC INSTABILITY; STROMA; MYOFIBROBLAST; GROWTH; METASTASIS; PHENOTYPE; INVASION; MICROENVIRONMENT; SENESCENT;

D O I：

10.1158/0008-5472.CAN-10-0785

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Although cancer-associated fibroblasts (CAF) are key determinants in the malignant progression of cancer, their functional contribution to this process is still unclear. Analysis of the mutual interplay between prostate carcinoma cells and CAFs revealed a mandatory role of carcinoma-derived interleukin-6 in fibroblast activation. In turn, activated fibroblasts through secretion of metalloproteinases elicit in cancer cells a clear epithelial-mesenchymal transition (EMT), as well as enhancement of tumor growth and development of spontaneous metastases. CAF-induced EMT leads prostate carcinoma cells to enhance expression of stem cell markers, as well as the ability to form prostaspheres and to self-renew. Hence, the paracrine interplay between CAFs and cancer cells leads to an EMT-driven gain of cancer stem cell properties associated with aggressiveness and metastatic spread. Cancer Res; 70(17); 6945-56. (C) 2010 AACR.

引用

页码：6945 / 6956

页数：12

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