Practical synthesis of a highly functionalized thiazole ketone

被引：28

作者：

Frey, LF ^{[1
]}

Marcantonio, KM ^{[1
]}

Chen, CY ^{[1
]}

Wallace, DJ ^{[1
]}

Murry, JA ^{[1
]}

Tan, LS ^{[1
]}

Chen, WR ^{[1
]}

Dolling, UH ^{[1
]}

Grabowski, EJJ ^{[1
]}

机构：

[1] Merck & Co Inc, Dept Proc Res, Merck Res Labs, Rahway, NJ 07065 USA

来源：

TETRAHEDRON | 2003年 / 59卷 / 33期

关键词：

thiazole ketone; anion; reaction; difluoromethylation; demethylation;

D O I：

10.1016/S0040-4020(03)00878-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Compound 1 is a uniquely substituted ketone prepared via addition of a thiazole anion to an aromatic nitrile in good overall yield. An exploration into the generality of the addition of thiazole anions to nitriles allowed us to make a variety of thiazole ketones in good to excellent yields. The non-odorous thiolate-mediated demethylation reaction used in the synthesis of 1 is also presented. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：6363 / 6373

页数：11

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