Development of new thiazole-based iridium catalysts and their applications in the asymmetric hydrogenation of trisubstituted olefins

被引：41

作者：

Cheruku, Pradeep ^{[1
]}

Paptchikhine, Alexander ^{[1
]}

Ali, Muhammad ^{[1
]}

Neudorfl, Jorg-M. ^{[1
]}

Andersson, Pher G. ^{[1
]}

机构：

[1] Uppsala Univ, Dept Biochem & Organ Chem, S-75123 Uppsala, Sweden

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2008年 / 6卷 / 02期

关键词：

D O I：

10.1039/b714744a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

New thiazole-based chiral N,P-ligands that are open-chain analogues of known cyclic thiazole ligands have been synthesized and evaluated in the iridium-catalyzed asymmetric hydrogenation of trisubstituted olefins. Chirality was introduced into the ligands through a highly diastereoselective alkylation using Oppolzer's camphorsultam as chiral auxiliary. In general, the new catalysts are as reactive and selective as their cyclic counterparts for the asymmetric hydrogenation of various trisubstituted olefins.

引用

页码：366 / 373

页数：8

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