Drugs and immunity: cannabinoids and their role in decreased resistance to infectious disease

被引：123

作者：

Cabral, GA ^{[1
]}

Pettit, DAD

机构：

[1] Virginia Commonwealth Univ, Med Coll Virginia, Dept Microbiol & Immunol, Richmond, VA 23298 USA

[2] Virginia Commonwealth Univ, Med Coll Virginia, Dept Pharmacol & Toxicol, Richmond, VA 23298 USA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 1998年 / 83卷 / 1-2期

关键词：

cannabinoids; delta-9-tetrahydrocannabinol; drugs and immunity; herpes simplex virus; marijuana;

D O I：

10.1016/S0165-5728(97)00227-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Marijuana, Cannabis sativa, elicits a variety of effects in experimental animals and humans. Delta-9-tetrahydrocannabinol (THC) is the major psychoactive component in marijuana. This substance has been shown, also, to be immunosuppressive and to decrease host resistance to bacterial, protozoan, and viral infections. Macrophages, T lymphocytes, and natural killer cells appear to be major targets of the immunosuppressive effects of THC. Definitive data which directly link marijuana use to increased susceptibility to infection in humans currently is unavailable. However, cumulative reports indicating that THC alters resistance to infection in vitro and in a variety of experimental animals support the hypothesis that a similar effect occurs in humans. (C) 1998 Elsevier Science B.V.

引用

页码：116 / 123

页数：8

共 57 条

[31] HOST DEFENSES IN HERPES-SIMPLEX INFECTIONS OF THE NERVOUS-SYSTEM - EFFECT OF ANTIBODY ON DISEASE AND VIRAL SPREAD
MCKENDALL, RR
KLASSEN, T
BARINGER, JR
[J]. INFECTION AND IMMUNITY, 1979, 23 (02) : 305 - 311
[32] DELTA-9-TETRAHYDROCANNABINOL DECREASES HOST-RESISTANCE TO HERPES-SIMPLEX VIRUS TYPE-2 VAGINAL INFECTION IN THE B6C3F1 MOUSE
MISHKIN, EM
CABRAL, GA
[J]. JOURNAL OF GENERAL VIROLOGY, 1985, 66 : 2539 - 2549
[33] COMPARISON OF ANTIVIRAL AND ANTITUMOR ACTIVITY OF ACTIVATED MACROPHAGES
MORAHAN, PS
GLASGOW, LA
CRANE, JL
KERN, ER
[J]. CELLULAR IMMUNOLOGY, 1977, 28 (02) : 404 - 415
[34] EFFECTS OF CANNABINOIDS ON HOST-RESISTANCE TO LISTERIA-MONOCYTOGENES AND HERPES-SIMPLEX VIRUS
MORAHAN, PS
KLYKKEN, PC
SMITH, SH
HARRIS, LS
MUNSON, AE
[J]. INFECTION AND IMMUNITY, 1979, 23 (03) : 670 - 674
[35] MORAHAN PS, 1977, J IMMUNOL, V119, P2030
[36] MOLECULAR CHARACTERIZATION OF A PERIPHERAL RECEPTOR FOR CANNABINOIDS
MUNRO, S
THOMAS, KL
ABUSHAAR, M
[J]. NATURE, 1993, 365 (6441) : 61 - 65
[37] Munson A. E., 1976, PHARM MARIJUANA, P187
[38] MUNSON AE, 1983, CANNABIS HLTH HAZARD, P257
[39] THE HUMAN TOXICITY OF MARIJUANA
NAHAS, G
LATOUR, C
[J]. MEDICAL JOURNAL OF AUSTRALIA, 1992, 156 (07) : 495 - 497
[40] NAHAS GG, 1991, ADV EXP MED BIOL, V288, P25

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