DNA immunotherapeutics: New potential treatment modalities for allergic disease

被引：20

作者：

Goodman, JS

Van Uden, JH

Kobayashi, H

Broide, D

Raz, E

机构：

[1] Univ Calif San Diego, Sch Med, Dept Med, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Sch Med, Stein Inst Res Aging, La Jolla, CA 92093 USA

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 1998年 / 116卷 / 03期

关键词：

genetic vaccination; allergy; prevention and treatment; immunostimulatory DNA sequences; Th1; DNA immunotherapeutics; CpG;

D O I：

10.1159/000023943

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Genetic immunization is a relatively new approach to vaccination, one that has generated considerable interest for its potential to prevent or treat a number of types of disease processes. Although initial work focused on potential applications in infectious disease, it was soon recognized that the antigen-specific Th1 response typically generated by genetic immunization protocols could also be useful for the treatment of allergic disease. In this review we present a summary of genetic vaccination and the related topic of immunostimulatory DNA sequences - which we collectively designate DNA immunotherapeutics - and discuss their potential for the prevention and therapy of allergic disease.

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收藏

页码：177 / 187

页数：11

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