Cutaneous GVHD is associated with the expansion of tissue-localized Th1 and not Th17 cells

被引：60

作者：

Broady, Raewyn ^{[1
,2
,3
]}

Yu, Jie

Chow, Vickie ^{[6
]}

Tantiworawit, Adisak ^{[2
,3
]}

Kang, Christine ^{[6
]}

Berg, Kyra

Martinka, Magdalena ^{[7
]}

Ghoreishi, Mehran ^{[4
,5
]}

Dutz, Jan ^{[4
,5
]}

Levings, Megan K. ^{[6
]}

机构：

[1] Univ British Columbia, Div Haematol, Dept Med, Vancouver, BC V5Z 1M9, Canada

[2] Vancouver Coastal Hlth Res Inst, Immun & Infect Res Ctr, Vancouver, BC, Canada

[3] Vancouver Coastal Hlth Res Inst, Leukemia Bone Marrow Transplant Program BC, Vancouver, BC, Canada

[4] Univ British Columbia, Child & Family Res Inst, Vancouver, BC V5Z 1M9, Canada

[5] Univ British Columbia, Dept Dermatol & Skin Sci, Vancouver, BC V5Z 1M9, Canada

[6] Univ British Columbia, Dept Surg, Vancouver, BC V5Z 1M9, Canada

[7] Univ British Columbia, Dept Pathol, Vancouver, BC V5Z 1M9, Canada

来源：

BLOOD | 2010年 / 116卷 / 25期

关键词：

VERSUS-HOST-DISEASE; IL-17; ABSENCE;

D O I：

10.1182/blood-2010-07-295436

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Studies in mice have shown that proinflammatory Th17 cells can cause acute graft-versus-host disease (aGVHD) related tissue damage; however, whether they play a role in human aGVHD remains unclear. In a prospective study, we measured the proportion of Th17 cells in the blood and skin of patients at the onset of aGVHD. We found no difference in the proportion or amount of IL-17 produced by T cells in the blood of patients with aGVHD (n = 20) compared with time-matched patients without GVHD (n = 14). Moreover, Th17 cells were not increased in the skin of patients with cutaneous aGVHD (n = 7) compared with healthy controls (n = 10). In contrast, we found significantly more interferon-gamma-producing T cells in the skin of patients with aGVHD compared with controls. These data support the long-standing paradigm that tissue localized interferon-gamma-producing cells are the perpetrators of aGVHD. (Blood. 2010;116(25):5748-5751)

引用

收藏

页码：5748 / 5751

页数：4

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