i-motif formation with locked nucleic acid (LNA)

被引：29

作者：

Kumar, Niti ^{[1
,2
]}

Nielsen, Jakob T. ^{[1
]}

Maiti, Souvik ^{[2
]}

Petersen, Michael ^{[1
]}

机构：

[1] Univ So Denmark, Nucle Acid Ctr, Dept Chem & Phys, DK-5230 Odense M, Denmark

[2] CSIR, Inst Gen & Integrat Biol, Prote & Struct Biol Unit, Delhi 110007, India

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 48期

关键词：

circular dichroism; DNA structures; i-motif; NMR spectroscopy; nucleic acids;

D O I：

10.1002/anie.200701667

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Dotting the i: The i-motif is a four-stranded DNA structure that consists of intercalated hemiprotonated C:C+ base pairs. Although they contain 2′-ribo oxygen atoms, LNA-modified TC5 oligonucleotides are also able to form stable tetrameric i-motif structures at low pH values (see view into one of the two narrow grooves of such a structure), as shown by a combination of CD, UV, and NMR spectroscopy. (Figure Presented) © 2007 Wiley-VCH Verlag GmbH S. Co. KGaA.

引用

页码：9220 / 9222

页数：3

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