Novel synthesis of carbapenam by intramolecular attack of lactam nitrogen toward η1-allenyl and η3-propargylpalladium complex

被引：52

作者：

Kozawa, Y ^{[1
]}

Mori, M ^{[1
]}

机构：

[1] Hokkaido Univ, Grad Sch Pharmaceut Sci, Sapporo, Hokkaido 0600812, Japan

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2003年 / 68卷 / 21期

关键词：

D O I：

10.1021/jo030123c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

When a THF solution of beta-lactam having propargyl phosphate was warmed in the presence of 5 mol % of Pd-2(dba)(3).CHCl3, 20 mol % of a bidentate ligand, and sodium acetate (1.5 equiv) at 40 degreesC for 22 h, carbapenam was produced in high yield. In this reaction, the lactam nitrogen attacked the central carbon of a eta(3)-propargylpalladium complex, which was formed from propargyl phosphate and Pd(0).

引用

页码：8068 / 8074

页数：7

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