Total synthesis of the nonadjacent bis-tetrahydrofuran annonaceous acetogenin squamostatin-D

被引：36

作者：

Marshall, JA ^{[1
]}

Jiang, HJ ^{[1
]}

机构：

[1] Univ Virginia, Dept Chem, Charlottesville, VA 22901 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1998年 / 63卷 / 20期

关键词：

D O I：

10.1021/jo981103r

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A total synthesis of the Annonaceous acetogenin squamostatin-D is described. Key adjacent stereocenters were introduced through enantioselective addition of chiral oxygenated allylic tin and indium reagents to aldehyde subunits. The isolated stereocenter at C12 was constructed through addition of a functionalized organozinc reagent to an aldehyde subunit in the presence of a chiral bis-sulfonamide-titanium catalyst.

引用

页码：7066 / 7071

页数：6

共 17 条

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