Engineering of radiolabeled iron oxide nanoparticles for dual-modality imaging

被引：49

作者：

Ai, Fanrong ^{[1
,2
]}

Ferreira, Carolina A. ^{[3
]}

Chen, Feng ^{[2
]}

Cai, Weibo ^{[2
,3
,4
,5
]}

机构：

[1] Nanchang Univ, Sch Mech & Elect Engn, Nanchang, Jiangxi, Peoples R China

[2] Univ Wisconsin, Dept Radiol, Madison, WI 53706 USA

[3] Univ Wisconsin, Dept Biomed Engn, Madison, WI 53706 USA

[4] Univ Wisconsin, Dept Med Phys, 1530 Med Sci Ctr, Madison, WI 53706 USA

[5] Univ Wisconsin, Carbone Canc Ctr, Madison, WI 53792 USA

来源：

WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY | 2016年 / 8卷 / 04期

基金：

美国国家卫生研究院; 中国国家自然科学基金;

关键词：

CU-64-LABELED MAGNETIC NANOPARTICLES; PET; PET/MRI; MRI; EFFICACY; DESIGN; ADSORPTION; PEGYLATION; EXPRESSION; ARSENITE;

D O I：

10.1002/wnan.1386

中图分类号：

TB3 [工程材料学];

学科分类号：

082905 [生物质能源与材料];

摘要：

Over the last decade, radiolabeled iron oxide nanoparticles have been developed as promising contrast agents for dual-modality positron emission tomography/magnetic resonance imaging (PET/MRI) or single-photon emission computed tomography/magnetic resonance imaging (SPECT/MRI). The combination of PET (or SPECT) with MRI can offer synergistic advantages for noninvasive, sensitive, high-resolution, and quantitative imaging, which is suitable for early detection of various diseases such as cancer. Here, we summarize the recent advances on radiolabeled iron oxide nanoparticles for dual-modality imaging, through the use of a variety of PET (and SPECT) isotopes by using both chelator-based and chelator-free radiolabeling techniques. (C) 2015 Wiley Periodicals, Inc.

引用

收藏

页码：619 / 630

页数：12

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