Regulation of reactive oxygen species generation in cell signaling

被引：507

作者：

Bae, Yun Soo ^{[1
]}

Oh, Hyunjin

Rhee, Sue Goo ^{[1
]}

Do Yoo, Young ^{[2
]}

机构：

[1] Ewha Womans Univ, Div Life & Pharmaceut Sci, Dept Life Sci, Seoul 120750, South Korea

[2] Korea Univ, Coll Med, Grad Sch Med, Mol Cell Biol Lab, Seoul 136705, South Korea

来源：

MOLECULES AND CELLS | 2011年 / 32卷 / 06期

基金：

新加坡国家研究基金会;

关键词：

apoptosis; cell signaling; cytochrome p450; mitochondria; NADPH oxidase; reactive oxygen species; NF-KAPPA-B; PROTEIN-KINASE-C; PHAGOCYTE NADPH OXIDASE; NECROSIS-FACTOR-ALPHA; GTP-BINDING PROTEIN; MITOCHONDRIAL P450 SYSTEMS; NEUTROPHIL CYTOCHROME-B; LOW-DENSITY-LIPOPROTEIN; SRC HOMOLOGY-3 DOMAINS; INDUCED ROS PRODUCTION;

D O I：

10.1007/s10059-011-0276-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Reactive oxygen species (ROS) including superoxide anion and hydrogen peroxide (H2O2) are thought to be byproducts of aerobic respiration with damaging effects on DNA, protein, and lipid. A growing body of evidence indicates, however, that ROS are involved in the maintenance of redox homeostasis and various cellular signaling pathways. ROS are generated from diverse sources including mitochondrial respiratory chain, enzymatic activation of cytochrome p450, and NADPH oxidases further suggesting involvement in a complex array of cellular processes. This review summarizes the production and function of ROS. In particular, how cytosolic and membrane proteins regulate ROS generation for intracellular redox signaling will be detailed.

引用

页码：491 / 509

页数：19

共 273 条

[11] Macrophages Generate Reactive Oxygen Species in Response to Minimally Oxidized Low-Density Lipoprotein Toll-Like Receptor 4-and Spleen Tyrosine Kinase-Dependent Activation of NADPH Oxidase 2 [J].