Estrogens in vascular biology and disease:: where do we stand today?

被引:60
作者
Arnal, Jean-Francois
Scarabin, Pierre-Yves
Tremollieres, Florence
Laurell, Henrik
Gourdy, Pierre
机构
[1] CHU Toulouse Rangueil, Dept Vasc Biol & Atherothrombosis, INSERM, U858,12MR, F-31432 Toulouse 4, France
[2] Hop Paul Brousse, Cardiovasc Epidemiol Team, Villejuif, France
关键词
atheroma; atherosclerosis; cardiovascular risk; oestrogens; thrombosis;
D O I
10.1097/MOL.0b013e3282ef3bca
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A better understanding of the balance between the deleterious and beneficial effects of estrogens is required and should help to improve hormonal therapy safety and to optimize the prevention of cardiovascular disease after menopause.
引用
收藏
页码:554 / 560
页数:7
相关论文
共 71 条
[1]   Effects of conjugated, equine estrogen in postmenopausal women with hysterectomy - The women's health initiative randomized controlled trial [J].
Anderson, GL ;
Limacher, M ;
Assaf, AR ;
Bassford, T ;
Beresford, SAA ;
Black, H ;
Bonds, D ;
Brunner, R ;
Brzyski, R ;
Caan, B ;
Chlebowski, R ;
Curb, D ;
Gass, M ;
Hays, J ;
Heiss, G ;
Hendrix, S ;
Howard, BV ;
Hsia, J ;
Hubbell, A ;
Jackson, R ;
Johnson, KC ;
Judd, H ;
Kotchen, JM ;
Kuller, L ;
LaCroix, AZ ;
Lane, D ;
Langer, RD ;
Lasser, N ;
Lewis, CE ;
Manson, J ;
Margolis, K ;
Ockene, J ;
O'Sullivan, MJ ;
Phillips, L ;
Prentice, RL ;
Ritenbaugh, C ;
Robbins, J ;
Rossouw, JE ;
Sarto, G ;
Stefanick, ML ;
Van Horn, L ;
Wactawski-Wende, J ;
Wallace, R ;
Wassertheil-Smoller, S .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2004, 291 (14) :1701-1712
[2]   Understanding the oestrogen action in experimental and clinical atherosclerosis [J].
Arnal, J. F. ;
Douin-Echinard, V. ;
Brouchet, L. ;
Tremollieres, F. ;
Laurell, H. ;
Lenfant, F. ;
Gadeau, A. P. ;
Guery, J. C. ;
Gourdy, P. .
FUNDAMENTAL & CLINICAL PHARMACOLOGY, 2006, 20 (06) :539-548
[3]   Ethinylestradiol does not enhance the expression of nitric oxide synthase in bovine endothelial cells but increases the release of bioactive nitric oxide by inhibiting superoxide anion production [J].
Arnal, JF ;
Clamens, S ;
Pechet, C ;
NegreSalvayre, A ;
Allera, C ;
Girolami, JP ;
Salvayre, R ;
Bayard, F .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (09) :4108-4113
[4]   Estrogen reduces atherosclerotic lesion development in apolipoprotein E-deficient mice [J].
Bourassa, PAK ;
Milos, PM ;
Gaynor, BJ ;
Breslow, JL ;
Aiello, RJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (19) :10022-10027
[5]  
Brouchet L, 2001, CIRCULATION, V103, P423
[6]   Obesity and risk of venous thromboembolism among postmenopausal women: differential impact of hormone therapy by route of estrogen administration. The ESTHER Study [J].
Canonico, M. ;
Oger, E. . ;
Conard, J. . ;
Meyer, G. ;
Levesque, H. ;
Trillot, N. ;
Barrellier, M. T. . ;
Wahl, D. ;
Emmerich, J. . ;
Scarabin, P. Y. .
JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2006, 4 (06) :1259-1265
[7]   Hormone therapy and venous thromboembolism among postmenopausal women -: Impact of the route of estrogen administration and progestogens:: The ESTHER study [J].
Canonico, Marianne ;
Oger, Emmanuel ;
Plu-Bureau, Genevieve ;
Conard, Jacqueline ;
Meyer, Guy ;
Levesque, Herve ;
Trillot, Nathalie ;
Barrellier, Marie-Therese ;
Wahl, Denis ;
Emmerich, Joseph ;
Scarabin, Pierre-Yves .
CIRCULATION, 2007, 115 (07) :840-845
[8]   Controversies about HRT - lessons from monkey models [J].
Clarkson, TB ;
Appt, SE .
MATURITAS, 2005, 51 (01) :64-74
[9]   Selective estrogen receptor modulators: Clinical spectrum [J].
Cosman, F ;
Lindsay, R .
ENDOCRINE REVIEWS, 1999, 20 (03) :418-434
[10]   ANALYSIS OF TRANSCRIPTION AND ESTROGEN INSENSITIVITY IN THE FEMALE MOUSE AFTER TARGETED DISRUPTION OF THE ESTROGEN-RECEPTOR GENE [J].
COUSE, JF ;
CURTIS, SW ;
WASHBURN, TF ;
LINDZEY, J ;
GOLDING, TS ;
LUBAHN, DB ;
SMITHIES, O ;
KORACH, KS .
MOLECULAR ENDOCRINOLOGY, 1995, 9 (11) :1441-1454