Conformationally constrained dipeptides.: Obtention of enantiomerically pure 6-acetamido-5-oxo-1,2,3,5,6,7-hexahydro-3-indolizine carboxylic acid

被引：9

作者：

Millet, R

Meulon, E

Goossens, L

Houssin, R

Hénichart, JP

Rigo, B

机构：

[1] Univ Lille 2, Inst Chim Pharmaceut Albert Lespagnol, F-59006 Lille, France

[2] Ecole Hautes Etud Ind, Lab Ingn Mol, F-59046 Lille, France

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2000年 / 37卷 / 06期

关键词：

D O I：

10.1002/jhet.5570370613

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The separation of a stereoisomeric mixture of esters 6, and the synthesis of the new enantiomerically pure unsaturated 6,5-fused bicyclic lactam 2 are described. The key-step involves trimethylsilyl iodide cleavage, without racemization, of a vinylogous carbamate. The cis N-acetylamino acid 2 is a new scaffold for the synthesis of rigid beta -turn mimetics.

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页码：1491 / 1494

页数：4

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