Mechanism of free radical oxygenation of polyunsaturated fatty acids by cyclooxygenases

被引:202
作者
Rouzer, CA
Marnett, LJ
机构
[1] Vanderbilt Univ, Sch Med,Dept Biochem,Ctr Mol Toxicol, Vanderbilt Inst Chem Biol,AB Hancock Jr Mem Lab C, Vanderbilt Ingram Comprehens Canc Ctr, Nashville, TN 37232 USA
[2] Vanderbilt Univ, Sch Med,Dept Chem, Vanderbilt Inst Chem Biol,Ctr Mol Toxicol, Vanderbilt Ingram Comprehens Canc Ctr, Nashville, TN 37232 USA
关键词
D O I
10.1021/cr000068x
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
COX proteins hold a special fascination for biomedical scientists because of the interesting chemistry they catalyze, the role of their PG products as mediators of signaling pathways, and the importance of the cyclooxygenase active sites as targets for a large and growing class of drugs that alleviate human suffering. Studies conducted over the past 15 years have provided strong support for the basic tenets of the branched-chain mechanism linking peroxidase catalysis to cyclooxygenase activation via the formation of a protein tyrosyl radical. Available data serve to show that the cyclooxygenase mechanism is one of the most well-understood of all those in radical enzymology"."
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收藏
页码:2239 / 2304
页数:66
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