Targeting non-malignant disorders with tyrosine kinase inhibitors

被引：113

作者：

Grimminger, Friedrich ^{[1
,2
]}

Schermuly, Ralph T. ^{[2
,3
]}

Ghofrani, Hossein A. ^{[1
,2
]}

机构：

[1] Univ Hosp Giessen & Marburg, Med Clin 2 4 5, D-35398 Giessen, Germany

[2] Univ Giessen, Lung Ctr, D-35398 Giessen, Germany

[3] Max Planck Inst Heart & Lung Res, D-61231 Bad Nauheim, Germany

来源：

NATURE REVIEWS DRUG DISCOVERY | 2010年 / 9卷 / 12期

关键词：

ENDOTHELIAL GROWTH-FACTOR; PULMONARY ARTERIAL-HYPERTENSION; GASTROINTESTINAL STROMAL TUMORS; CHRONIC MYELOGENOUS LEUKEMIA; ACUTE MYELOID-LEUKEMIA; SMOOTH-MUSCLE-CELLS; FACTOR-RECEPTOR-BETA; ORGAN ALLOGRAFT-REJECTION; PLACEBO-CONTROLLED TRIAL; FOCAL ADHESION KINASE;

D O I：

10.1038/nrd3297

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Receptor and non-receptor tyrosine kinases are involved in multiple proliferative signalling pathways. Imatinib, one of the first tyrosine kinase inhibitors (TKIs) to be approved, revolutionized the treatment of chronic myelogenous leukaemia, and other TKIs with different spectra of kinase inhibition are used to treat renal cell carcinoma, non-small-cell lung cancer and colon cancer. Studies also support the potential use of TKIs as anti-proliferative agents in non-malignant disorders such as cardiac hypertrophy, and in benign-proliferative disorders including pulmonary hypertension, lung fibrosis, rheumatoid disorders, atherosclerosis, in-stent restenosis and glomerulonephritis. In this Review, we provide an overview of the most recent developments-both experimental as well as clinical-regarding the therapeutic potential of TKIs in non-malignant disorders.

引用

页码：956 / 970

页数：15

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