Cross-talk between IL-6 and TGF-β signaling in hepatoma cells

被引：66

作者：

Yamamoto, T

Matsuda, T

Muraguchi, A

Miyazono, K

Kawabata, M

机构：

[1] Toyama Med & Pharmaceut Univ, Fac Med, Dept Immunol, Toyama 9300194, Japan

[2] Japanese Fdn Canc Res, Inst Canc, Dept Biochem, Toshima Ku, Tokyo 1708455, Japan

来源：

FEBS LETTERS | 2001年 / 492卷 / 03期

关键词：

interleukin-6; signal transducer and activator of transcription-3; transforming growth factor-beta; Sma- and MAD-related protein; p300; cross-talk; transcription;

D O I：

10.1016/S0014-5793(01)02258-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Interleukin-6 (IL-6) is a multifunctional cytokine that plays important roles in the immune system, hematopoiesis, and acute phase reactions. Transforming growth factor-beta (TGF-beta) also has pleiotropy including the production of acute phase proteins in hepatocytes, To elucidate the cross-talk between IL-6 and TGF-beta signaling pathways in hepatic cells, we investigated the effects of TGF-beta on IL-6-induced signal transducer and activator of transcription-3 (STAT3) activation in a human hepatoma cell line, Hep3B, IL-6-induccd activation of STAT3 activity and STAT3-mediated gene expression were augmented by TGF-beta in Hep3B cells, We provide evidence that these activities were due to physical interactions between STAT3 and Sma- and MAD-related protein-3, bridged by p300. These results demonstrate a molecular mechanism of a cross-talk between STAT3 and TGF-beta signaling pathways in hepatocytes, (C) 2001 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：247 / 253

页数：7

共 24 条

[21] Stat protein transactivation domains recruit p300/CBP through widely divergent sequences [J].