Reuptake of L-DOPA-Derived extracellular DA in the striatum of a rodent model of Parkinson's disease via norepinephrine transporter

被引：47

作者：

Arai, Akira ^{[1
]}

Tomiyama, Masahiko ^{[1
]}

Kannari, Kazuya ^{[1
]}

Kimura, Tamaki ^{[1
]}

Suzuki, Chieko ^{[1
]}

Watanabe, Mitsunori ^{[1
]}

Kawarabayashi, Takeshi ^{[1
]}

Shen, Huo ^{[1
]}

Shoji, Mikio ^{[1
]}

机构：

[1] Hirosaki Univ, Dept Neurol, Inst Brain Sci, Grad Sch Med, Hirosaki, Aomori 0368562, Japan

来源：

SYNAPSE | 2008年 / 62卷 / 08期

关键词：

desipramine; dopaminergic denervation; 6-hydroxyDA; norepinephrine transporter; microdialysis; reuptake;

D O I：

10.1002/syn.20535

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

To determine the role of norepinephrine transporter in reuptake Of LDOPA-derived extracellular DA in the DA-denervated Parkinsonian striatum, we examined extracellular DA levels in the striatum of 6-hydroxyDA-lesioned rats that received L-DOPA (50 mg/kg with 12.5 mg/kg of benserazide) and L-DOPA plus desipramine (25 mg/kg), a selective norepinephrine reuptake inhibitor, using in vivo microdialysis. The pretreatment with desipramine increased levels of extracellular DA derived from administrated L-DOPA in the DA-denervated striatum. This study provides evidence that L-DOPA-derived DA is taken up by the norepinephrine transporter, instead of the dopamine transporter, in the striatum with doparninergic denervation. This result suggests that the norepinephrine transporter could be a promising target in the treatment for Parkinson's disease.

引用

页码：632 / 635

页数：4

共 21 条

[11] Reuptake of L-DOPA-derived extracellular dopamine in the striatum with dopaminergic denervation via serotonin transporters [J].

Kannari, Kazuya ;

Shen, Huo ;

Arai, Akira ;

Tomiyama, Masahiko ;

Baba, Masayuki .

NEUROSCIENCE LETTERS, 2006, 402 (1-2) :62-65

[12] Loss of regulation by presynaptic dopamine D2 receptors of exogenous L-DOPA-derived dopamine release in the dopaminergic denervated striatum [J].

Maeda, T ;

Kannari, K ;

Suda, T ;

Matsunaga, M .

BRAIN RESEARCH, 1999, 817 (1-2) :185-191

[13] The 'magic' of L-dopa: why is it the gold standard Parkinson's disease therapy? [J].

Mercuri, NB ;

Bernardi, G .

TRENDS IN PHARMACOLOGICAL SCIENCES, 2005, 26 (07) :341-344

[14] Dopamine uptake through the norepinephrine transporter in brain regions with low levels of the dopamine transporter:: Evidence from knock-out mouse lines [J].

Morón, JA ;

Brockington, A ;

Wise, RA ;

Rocha, BA ;

Hope, BT .

JOURNAL OF NEUROSCIENCE, 2002, 22 (02) :389-395

[15] Levodopa in the treatment of Parkinson's disease: Current controversies [J].

Olanow, CW ;

Agid, Y ;

Mizuno, Y ;

Albanese, A ;

Bonucelli, U ;

Damier, P ;

De Yebenes, J ;

Gershanik, O ;

Guttman, M ;

Grandas, F ;

Hallett, M ;

Hornykiewicz, O ;

Jenner, P ;

Katzenschlager, R ;

Langston, WJ ;

LeWitt, P ;

Melamed, E ;

Mena, MA ;

Michel, PP ;

Mytilineou, C ;

Obeso, JA ;

Poewe, W ;

Quinn, N ;

Rajput, AH ;

Rascol, O ;

Sampaio, C ;

Stocchi, F .

MOVEMENT DISORDERS, 2004, 19 (09) :997-1005

[16]

Paxinos G, 1998, RAT BRAIN

[17] EFFECT OF SYMPATHOMIMETIC AMINES ON SYNAPTOSOMAL TRANSPORT OF NORADRENALINE, DOPAMINE AND 5-HYDROXYTRYPTAMINE [J].

RAITERI, M ;

DELCARMINE, R ;

BERTOLLINI, A ;

LEVI, G .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1977, 41 (02) :133-143

[18] Role of serotonergic neurons in L-DOPA-derived extracellular dopamine in the striatum of 6-OHDA-lesioned rats [J].

Tanaka, H ;

Kannari, K ;

Maeda, T ;

Tomiyama, M ;

Suda, T ;

Matsunaga, M .

NEUROREPORT, 1999, 10 (03) :631-634

[19] A serotonin 5-HT1A receptor agonist prevents behavioral sensitization to L-DOPA in a rodent model of Parkinson's disease [J].

Tomiyama, M ;

Kimura, T ;

Maeda, T ;

Kannari, K ;

Matsunaga, M ;

Baba, M .

NEUROSCIENCE RESEARCH, 2005, 52 (02) :185-194

[20] Estimation of striatal dopamine spillover and metabolism in vivo [J].

Yadid, G ;

Harvey-White, JD ;

Kopin, IJ ;

Goldstein, DS .

NEUROREPORT, 2000, 11 (15) :3367-3373

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