NEW INSIGHTS INTO THE ROLE OF MITOCHONDRIA-ASSOCIATED ENDOPLASMIC RETICULUM MEMBRANE

被引:83
作者
Fujimoto, Michiko [1 ]
Hayashi, Teruo [1 ]
机构
[1] Natl Inst Drug Abuse, Cellular Stress Signaling Unit, Cellular Pathobiol Sect,DHHS, Integrat Neurosci Branch,Intramural Res Program,N, Baltimore, MD USA
来源
INTERNATIONAL REVIEW OF CELL AND MOLECULAR BIOLOGY, VOL 292 | 2011年 / 292卷
关键词
Endoplasmic reticulum; Mitochondria; MAM; Mitochondria-associated membrane; Calcium signaling; Phospholipids; Apoptosis; RAT-LIVER MITOCHONDRIA; CALCIUM SIGNAL TRANSMISSION; SIGMA-1; RECEPTORS; SARCOPLASMIC-RETICULUM; RYANODINE RECEPTORS; ALZHEIMERS-DISEASE; GOLGI-APPARATUS; ACYL-COENZYME; LIPID RAFTS; SUBCELLULAR COMPARTMENTALIZATION;
D O I
10.1016/B978-0-12-386033-0.00002-5
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The mitochondria-associated endoplasmic reticulum membrane (MAM) is a specialized subdomain of the endoplasmic reticulum (ER) membrane that regulates ER mitochondria communications. The MAM is characterized by direct apposition to a mitochondrion, a unique lipid profile, and the expression of a unique set of proteins involved in Ca2+ signaling, phospholipid biosynthesis, protein folding, and membrane tethering. The association of the MAM with a mitochondrion is in part cytoskeleton independent and dynamically changed by an elevation of the cytosolic Ca2+ level. The mechanisms underlying the genesis of MAM are unclear but might involve COPI-dependent vesicular transport and soluble NSF attachment protein receptor. The MAM is recognized as a center for intermembrane transport of phospholipids and for direct Ca2+ transmission to mitochondria that activates the tricarboxylic acid cycle. However, MAM might be also involved in the interorganelle transport of cholesterol, ceramides, ATP, and proteins as well as in proteasomal protein degradation and lipid droplet formation. Recent studies have begun to unveil the importance of interorganelle communication in the innate immune response to virus infection and in the pathophysiology of neurodegenerative/neurodevelopmental disorders. Thus, drug discovery aimed at regulating ER-to-mitochondria communication may open a new avenue in treatments of human diseases.
引用
收藏
页码:73 / 117
页数:45
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