Fatty acid transport proteins: a current view of a growing family

被引：186

作者：

Stahl, A

Gimeno, RE

Tartaglia, LA

Lodish, HF

机构：

[1] Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

[2] Millennium Pharmaceut Inc, Cambridge, MA 02139 USA

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2001年 / 12卷 / 06期

关键词：

D O I：

10.1016/S1043-2760(01)00427-1

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Long-chain fatty acids (LCFAs) are a major caloric component of our diet and are key metabolites for energy generation and storage. Physiological uptake of LCFAs across cell membranes is a saturable and competable process occurring at low concentrations, indicative of protein-mediated transport. Fatty acid transport proteins are a family of transmembrane proteins that enhance LCFA uptake and are produced in all fatty acid-utilizing tissues. Here, we review our current understanding of the function, expression patterns and regulation and subcellular localization of this interesting family of proteins.

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页码：266 / 273

页数：8

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