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c-Src tyrosine phosphorylation of epidermal growth factor receptor, P190 RhoGAP, and focal adhesion kinase regulates diverse cellular processes

被引：54
作者：
Haskell, MD
Slack, JK
Parsons, JT
Parsons, SJ
机构：
[1] Univ Virginia, Dept Microbiol, Charlottesville, VA 22908 USA
[2] Univ Virginia, Ctr Canc, Charlottesville, VA 22908 USA
来源：
CHEMICAL REVIEWS | 2001年 / 101卷 / 08期
关键词：
D O I：
10.1021/cr0002341
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A study c-Src phosphorylation of epidermal growth factor receptor, P190 RhoGAP, was presented. c-Src structure, function, and role in human cancers was discussed. It was found that cellular adhesion regulated the growth and motility by signaling through FAK (focal adhesion kinase)/Src tyrosine kinase complexes. Alterations in adhesion-dependent signal transduction regulated tumor metasis by conferring typically nonmotile cells the ability to detach from native ECM and migrate to distal sites.
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收藏
页码：2425 / 2440
页数：16
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