Mispairing C57BL/6 Substrains of Genetically Engineered Mice and Wild-Type Controls Can Lead to Confounding Results as It Did in Studies of JNK2 in Acetaminophen and Concanavalin A Liver Injury

被引：70

作者：

Bourdi, Mohammed ^{[1
]}

Davies, John S. ^{[1
]}

Pohl, Lance R. ^{[1
]}

机构：

[1] NHLBI, Mol & Cellular Toxicol Sect, Lab Mol Immunol, NIH,Dept Hlth & Human Serv, Bethesda, MD 20892 USA

来源：

CHEMICAL RESEARCH IN TOXICOLOGY | 2011年 / 24卷 / 06期

基金：

美国国家卫生研究院;

关键词：

TERMINAL KINASE; DIFFERENTIAL SUSCEPTIBILITY; BEHAVIORAL-DIFFERENCES; COPY NUMBER; KNOCKOUT;

D O I：

10.1021/tx200143x

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

C57BL/6 mice are widely used in biomedical research for the background of genetically engineered mice (GEM) and wild-type controls With the belief that the genetic background of GEM and control mice differ significantly by only one or more altered genes. This principle, however, does have limitations due in part to the existence of multiple substrains of C57BL/6 mice that should not be used interchangeably as they can differ both genetically and phenotypically. We show here that these mispairings do occur frequently and can lead to inaccurate and conflicting findings.

引用

页码：794 / 796

页数：3