Leptospirosis-associated severe pulmonary hemorrhagic syndrome, Salvador, Brazil

被引:191
作者
Gouvela, Edilane L. [1 ]
Metcalfe, John [2 ]
de Carvalho, Ana Luiza F. [1 ]
Aires, Talita S. F. [1 ]
Villasboas-Bisneto, Jose Caetano [1 ]
Queirroz, Adriano [1 ]
Santos, Andreia G. [1 ]
Salgado, Katia [3 ]
Reis, Mitermayer G. [1 ]
Ko, Albert I. [1 ,4 ]
机构
[1] Ctr Pesquisas Goncalo Moniz, Fundacao Oswaldi Cruz, Minist Saude, BR-40296 Salvador, BA, Brazil
[2] Univ Calif San Francisco, San Francisco, CA 94143 USA
[3] Hosp Couto Maia, Secretaria Saude Estado Bahia, Salvador, BA, Brazil
[4] Cornell Univ, Weill Med Coll, New York, NY USA
关键词
D O I
10.3201/eid1403.071064
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
We report the emergence of leptospirosis-associated severe pulmonary hemorrhagic syndrome (SPHS) in slum communities in Salvador, Brazil. Although active surveillance did not identify SPHS before 2003, 47 cases were identified from 2003 through 2005; the case-fatality rate was 74%. By 2005, SPHS caused 55% of the deaths due to leptospirosis.
引用
收藏
页码:505 / 508
页数:4
相关论文
共 15 条
[1]   Identification of new repetitive element in Leptospira interrogans serovar copenhageni and its application to PCR-based differentiation of Leptospira serogroups [J].
Barocchi, MA ;
Ko, AI ;
Ferrer, SR ;
Faria, MT ;
Reis, MG ;
Riley, LW .
JOURNAL OF CLINICAL MICROBIOLOGY, 2001, 39 (01) :191-195
[2]  
Goncalves A J, 1992, Rev Soc Bras Med Trop, V25, P261
[3]   Urban epidemic of severe leptospirosis in Brazil [J].
Ko, AI ;
Reis, MG ;
Dourado, CMR ;
Johnson, WD ;
Riley, LW .
LANCET, 1999, 354 (9181) :820-825
[4]   Leptospirosis [J].
Levett, PN .
CLINICAL MICROBIOLOGY REVIEWS, 2001, 14 (02) :296-+
[5]   Acute lung injury in leptospirosis: Clinical and laboratory features, outcome, and factors associated with mortality [J].
Marotto, PCF ;
Nascimento, CMR ;
Eluf-Neto, J ;
Marotto, MS ;
Andrade, L ;
Sztajnbok, J ;
Seguro, AC .
CLINICAL INFECTIOUS DISEASES, 1999, 29 (06) :1561-1563
[6]   Leptospirosis [J].
McBride, AJA ;
Athanazio, DA ;
Reis, MG ;
Ko, AI .
CURRENT OPINION IN INFECTIOUS DISEASES, 2005, 18 (05) :376-386
[7]   Evaluation of four whole-cell Leptospira-based serological tests for diagnosis of urban leptospirosis [J].
McBride, Alan J. A. ;
Santos, Balbino L. ;
Queiroz, Adriano ;
Santos, Andreia C. ;
Hartskeerl, Rudy A. ;
Reis, Mitermayer G. ;
Ko, Albert I. .
CLINICAL AND VACCINE IMMUNOLOGY, 2007, 14 (09) :1245-1248
[8]   Lung lesions in human leptospirosis: Microscopic, immunohistochemical, and ultrastructural features related to thrombocytopenia [J].
Nicodemo, AC ;
Duarte, MIS ;
Alves, VAF ;
Takakura, CFH ;
Santos, RTM ;
Nicodemo, EL .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1997, 56 (02) :181-187
[9]  
Panaphut Thanachai, 2002, International Journal of Infectious Diseases, V6, P52, DOI 10.1016/S1201-9712(02)90137-2
[10]   LEPTOSPIROSIS IN CHONBUK PROVINCE OF KOREA IN 1987 - A STUDY OF 93 PATIENTS [J].
PARK, SK ;
LEE, SH ;
RHEE, YK ;
KANG, SK ;
KIM, KJ ;
KIM, MC ;
KIM, KW ;
CHANG, WH .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1989, 41 (03) :345-351