Non-peptidic chymase inhibitors

被引：6

作者：

Aoyama, Y ^{[1
]}

机构：

[1] Shionogi & Co Ltd, Shionogi Res Labs, Fukushima Ku, Osaka 5530002, Japan

来源：

EXPERT OPINION ON THERAPEUTIC PATENTS | 2001年 / 11卷 / 09期

关键词：

cardiovascular disease; chymase; enzyme inhibitor; fibrosis; inflammatory disease; serine protease;

D O I：

10.1517/13543776.11.9.1423

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Human chymase is a chymotrypsin-like serine protease. Although the physiological and pathological roles of chymase have not been fully elucidated, recent studies have implicated its involvement in numerous physiological functions. Preliminary results suggest a wide therapeutic utility for chymase inhibitors in disorders such as heart failure, hypertension, chronic inflammation, allergy, dermatitis, rheumatoid arthritis and asthma. This review will focus on patent applications describing non-peptidic chymase inhibitors published within the last five years.

引用

页码：1423 / 1428

页数：6

共 47 条

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