1-Oxacephem-based human chymase inhibitors: Discovery of stable inhibitors in human plasma

被引：18

作者：

Aoyama, Y ^{[1
]}

Uenaka, M

Konoike, T

Iso, Y

Nishitani, Y

Kanda, A

Naya, N

Nakajima, M

机构：

[1] Shionogi & Co Ltd, Shionogi Res Labs, Fukushima Ku, Osaka 5530002, Japan

[2] Shionogi & Co Ltd, Shionogi Res Labs, Amagasaki, Hyogo 6600813, Japan

[3] Shionogi & Co Ltd, Shionogi Res Labs, Toyonaka, Osaka 5610825, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 21期

关键词：

D O I：

10.1016/S0960-894X(00)00489-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

1-Oxacephem derivatives were evaluated as a novel series of chymase inhibitors. The structure-activity relationship studies of 1-oxacephems led to compounds 15, which exhibited 27 nM inhibition of human chymase and improvement of stability in human plasma (t(1/2) 1.5 h), (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：2403 / 2406

页数：4

共 11 条

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