Achilles tendon healing in rats is improved by intermittent mechanical loading during the inflammatory phase

被引:56
作者
Eliasson, Pernilla [1 ]
Andersson, Therese [1 ]
Aspenberg, Per [1 ]
机构
[1] Linkoping Univ, Fac Hlth Sci, Dept Clin & Expt Med, S-58185 Linkoping, Sweden
基金
瑞典研究理事会;
关键词
early loading; tail-suspension; unloading; mechanical testing; treatment; PATELLAR TENDON; GENE-EXPRESSION; IMMOBILIZATION; COLLAGEN; MODEL; REHABILITATION; REPAIR;
D O I
10.1002/jor.21511
中图分类号
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学(修复外科学)];
学科分类号
摘要
Tendons adapt to changes in mechanical loading, and numerous animal studies show that immobilization of a healing tendon is detrimental to the healing process. The present study addresses whether the effects of a few episodes of mechanical loading are different during different phases of healing. Fifty female rats underwent Achilles tendon transection, and their hind limbs were unloaded by tail suspension on the day after surgery. One group of 10 rats was taken down from suspension to run on a treadmill for 30?min/day, on days 25 after transection. They were euthanized on day 8. Another group underwent similar treadmill running on days 811 and was euthanized on day 14. Continuously unloaded groups were euthanized on days 8 and 14. Tendon specimens were then evaluated mechanically. The results showed that just four loading episodes increased the strength of the healing tendon. This was evident irrespective of the time point when loading was applied (early or late). The positive effect on early healing was unexpected, considering that the mechanical stimulation was applied during the inflammatory phase, when the calluses were small and fragile. A histological study of additional groups with early loading also showed some increased bleeding in the loaded calluses. Our results indicate that a short episodes of early loading may improve the outcome of tendon healing. This could be of interest to clinical practice. (C) 2011 Orthopaedic Research Society Published by Wiley Periodicals, Inc. J Orthop Res 30:274279, 2012
引用
收藏
页码:274 / 279
页数:6
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