Tissue memory in healing tendons: short loading episodes stimulate healing

被引:45
作者
Andersson, Therese [1 ]
Eliasson, Pernilla [1 ]
Aspenberg, Per [1 ]
机构
[1] Linkoping Univ, Fac Hlth Sci, AIR IKE, SE-58183 Linkoping, Sweden
基金
瑞典研究理事会;
关键词
hindlimb suspension; immobilization; Achilles tendon; tendon healing; mechanical stimulation; ACHILLES-TENDON; IMMOBILIZATION; MODEL; MOBILIZATION; REPAIR;
D O I
10.1152/japplphysiol.00414.2009
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Andersson T, Eliasson P, Aspenberg P. Tissue memory in healing tendons: short loading episodes stimulate healing. J Appl Physiol 107: 417-421, 2009. First published June 18, 2009; doi:10.1152/japplphysiol.00414.2009.-Intact tendons adapt slowly to changes in mechanical loading, whereas in healing tendons the effect of mechanical loading or its absence is dramatic. The longevity of the response to a single loading episode is, however, unknown. We hypothesized that the tissue has a "memory" of loading episodes and that therefore short loadings are sufficient to elicit improved healing. The Achilles tendon of 70 female rats was transected and unloaded by tail suspension for 12 days (suspension started on day 2 after surgery). Each day, the rats were let down from suspension for short daily training episodes according to different regimes: 15 min of cage activity or treadmill running for 15, 30, 60, or 2 x 15 min. Rats with transected Achilles tendons and full-time cage activity served as controls. The results demonstrated that full-time cage activity increased the peak force over three times compared with unloading. Short daily loading episodes (treadmill running) increased the peak force about half as much as full-time activity. Prolongation of treadmill running above 15 min or dividing the daily training in two separate episodes had minimal further effect. This mechanical stimulation increased the cross-sectional area but had no effect on the mechanical properties of the repair tissue. The findings indicate that once the tissue had received information from a certain loading type and level, this is "memorized" and leads to a response lasting many hours. This suggests that patients might be allowed early short loading episodes following, e. g., an Achilles tendon rupture for a better outcome.
引用
收藏
页码:417 / 421
页数:5
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