Selective access and full characterization of mono-acidic permethylated β-cyclodextrin derivatives and their methyl esters

被引：11

作者：

Tisse, S

Peulon-Agasse, V

Oulyadi, H

Marsais, F

Combret, JC ^{[1
]}

机构：

[1] Univ Rouen, INSA Rouen, UPRES EA 2659, F-76821 Mont St Aignan, France

[2] Univ Rouen, INSA Rouen, UMR 6014, Lab RMN, F-76821 Mont St Aignan, France

[3] Univ Rouen, INSA Rouen, UMR 6014, Equipe Chim Organ Fine & Heterocycl, F-76821 Mont St Aignan, France

来源：

TETRAHEDRON-ASYMMETRY | 2003年 / 14卷 / 15期

关键词：

D O I：

10.1016/S0957-4166(03)00446-4

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Three acidic derivatives of permethylated beta-cyclodextrin, 2(I)-O-carboxymethyl-2(II-VII),3(I-VII),6(I-VII)-eicosa-O-methyl-cyclomaltoheptaose, 6(I)-O-carboxymethyl-2(I-VII),3(I-VII),6(II-VII)-eicosa-O-methyl-cyclomaltoheptaose, 6(I)-desoxy-6(I)-carboxy-2(I-VII),3(I-III),6(II-VII)-eicosa-O-methyl-cyclomaltoheptaose and the corresponding methyl esters have been synthesized with good yields starting from mono-hydroxy permethylated beta-CD prepared via tert-butyldimethylsilyl protection in 6-position and p-methoxybenzyl protection at the 2-position. All of these compounds were fully characterized by high field H-1 and C-13 NMR and HPLC/MS. (C) 2003 Elsevier Ltd. All rights reserved.

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页码：2259 / 2266

页数：8

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