Genomic structure, chromosome location, and alternative splicing of the human NKG2A gene

被引：72

作者：

Plougastel, B ^{[1
]}

Jones, T ^{[1
]}

Trowsdale, J ^{[1
]}

机构：

[1] IMPERIAL CANC RES FUND, HUMAN CYTOGENET LAB, LONDON WC2A 3PX, ENGLAND

来源：

IMMUNOGENETICS | 1996年 / 44卷 / 04期

关键词：

D O I：

10.1007/BF02602558

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A cosmid containing the human NKG2A gene was isolated. The gene was partially sequenced, revealing 7 exons, including one 5' untranslated exon. The 54 base pair exon 5 was missing in the published cDNA clone NKG2B, consistent with the existence of differential splicing. This was confirmed by reverse transcription-polymerase chain reaction of total RNA from normal lymphocytes. The NKG2A gene was mapped by FISH to chromosome 12p12.3-p13.1 in proximity to the CD69 and Prp genes. These data support the presence of a human lectin-like NK gene complex, analogous to the NK complex on mouse chromosome 6.

引用

页码：286 / 291

页数：6