The role of leukocyte-stromal interactions in chronic inflammatory joint disease

被引：15

作者：

Burman, A

Haworth, O

Bradfield, P

Parsonage, G

Filer, A

Thomas, AMC

Amft, N

Salmon, M

Buckley, CD ^{[1
]}

机构：

[1] Univ Birmingham, Rheumatol Res Grp, Inst Biomed Res, Div Immun & Infect,MRC Ctr Immune Regulat, Birmingham B15 2TT, W Midlands, England

[2] Royal Orthopaed Hosp, NHS Trust, Birmingham B31 2AP, W Midlands, England

来源：

JOINT BONE SPINE | 2005年 / 72卷 / 01期

关键词：

rheumatoid arthritis; cytokines; chemokines; synovitis; inflammation;

D O I：

10.1016/j.jbspin.2004.03.009

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Rheumatoid arthritis (RA) is a debilitating, chronic, persistent inflammatory disease that is characterised by painful and swollen joints. The aetiology of RA is unknown, however whereas past research has concentrated on the role of immune or inflammatory infiltrating cells in inflammation, it is becoming clear that stromal cells play a critical part in regulating the quality and duration of an inflammatory response. In this review we assess the role of fibroblasts within the inflamed synovium in modulating immune responses in particular we examine the role of stromal cells in the switch from resolving to persistent inflammation as is found in the rheumatoid synovium. (C) 2004 Elsevier SAS. All rights reserved.

引用

页码：10 / 16

页数：7

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