Facile solid phase synthesis of an activated diazo linker

被引：14

作者：

Bhalay, G ^{[1
]}

Dunstan, AR ^{[1
]}

机构：

[1] Novartis Horsham Res Ctr, Horsham RH12 5AB, W Sussex, England

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 42期

关键词：

diazo compounds; hydrazones; racemisation; solid phase synthesis;

D O I：

10.1016/S0040-4039(98)01706-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of a resin bound diazo species has been achieved in a highly efficient manner starting from commercially available reagents. This has produced an activated linker, providing a chemoselective method for the attachment of functionalised carboxylic acids to the solid phase via the Wang linker, in a rapid and colourometric reaction. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：7803 / 7806

页数：4

共 11 条

[1]

[Anonymous], ANGEW CHEM INT EDIT, DOI DOI 10.1002/ANIE.199622881

[2] Solid-phase synthesis of diverse tetrahydro-1,4-benzodiazepine-2-ones [J].

Bhalay, G ;

Blaney, P ;

Palmer, VH ;

Baxter, AD .

TETRAHEDRON LETTERS, 1997, 38 (48) :8375-8378

[3] DIVERSOMERS - AN APPROACH TO NONPEPTIDE, NONOLIGOMERIC CHEMICAL DIVERSITY [J].

DEWITT, SH ;

KIELY, JS ;

STANKOVIC, CJ ;

SCHROEDER, MC ;

CODY, DMR ;

PAVIA, MR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (15) :6909-6913

[4] REDUCTIVE ALKYLATION ON A SOLID-PHASE - SYNTHESIS OF A PIPERAZINEDIONE COMBINATORIAL LIBRARY [J].

GORDON, DW ;

STEELE, J .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1995, 5 (01) :47-50

[5]

Jones J.H., 1991, CHEM SYNTHESIS PEPTI

[6]

NFZI A, 1997, CHEM REV, P449

[7]

REESE CB, 1982, SYNTHESIS-STUTTGART, V5, P419

[8]

SAMMAKIA T, 1995, REAGENTS ORGANIC SYN, P3969

[9] COMBINATORIAL SYNTHESIS - THE DESIGN OF COMPOUND LIBRARIES AND THEIR APPLICATION TO DRUG DISCOVERY [J].

TERRETT, NK ;

GARDNER, M ;

GORDON, DW ;

KOBYLECKI, RJ ;

STEELE, J .

TETRAHEDRON, 1995, 51 (30) :8135-8173

[10]

TERRETT NK, 1998, COMBINATORIAL CHEM

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