Cross-Coupling of Nonactivated Alkyl Halides with Alkynyl Grignard Reagents: A Nickel Pincer Complex as the Catalyst

被引：104

作者：

Vechorkin, Oleg ^{[1
]}

Godinat, Aurelien ^{[1
]}

Scopelliti, Rosario ^{[1
]}

Hu, Xile ^{[1
]}

机构：

[1] Ecole Polytech Fed Lausanne EPFL, Inst Chem Sci & Engn, SB ISIC LSCI, CH-1015 Lausanne, Switzerland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 49期

基金：

瑞士国家科学基金会;

关键词：

alkylation; alkynes; cross-coupling; Grignard reaction; nickel; NUCLEOPHILES; BROMIDES; LIGAND; NI; ELECTROPHILES; IODIDES; ARYL;

D O I：

10.1002/anie.201105964

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In a pinch: The nickel pincer complex 1 catalyzes the cross-coupling of the title compounds with remarkable substrate scope and functional group tolerance. A nickel/alkynyl species was isolated and shown to be catalytically competent. THF=tetrahydrofuran, O-TMEDA=bis[2-(N,N-dimethylaminoethyl)] ether. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

收藏

页码：11777 / 11781

页数：5

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