Cephalostatin synthesis. 15. Synthesis of the South unit of cephalostatin. 7. Total syntheses of (+)-cephalostatin 7, (+)-cephalostatin 12, and (+)-ritterazine K

被引：59

作者：

Jeong, JU ^{[1
]}

Guo, CX ^{[1
]}

Fuchs, PL ^{[1
]}

机构：

[1] Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1999年 / 121卷 / 10期

关键词：

D O I：

10.1021/ja9817141

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Transformation of alcohol 4 to alpha-azidoketone 6, a hexacyclic steroid bearing the requisite functionality and spiroketal stereochemistry of the symchiral South portion of cephalostatin 7 (10) is described. Reaction of a 1:1 mixture of alpha-azidoketones 5 and 6 with sodium hydrogen telluride is followed by cleavage of the protecting groups cephalostatin 12 (9), cephalostatin 7 (10), and ritterazine K (11).

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页码：2071 / 2084

页数：14

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