Reductively labile PRINT particles for the delivery of doxorubicin to HeLa cells

被引：106

作者：

Petros, Robby A. ^{[1
]}

Ropp, Patricia A. ^{[1
]}

DeSimone, Josep M. ^{[1
]}

机构：

[1] Univ N Carolina, Dept Chem, Caudill Labs, Chapel Hill, NC 27599 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2008年 / 130卷 / 15期

关键词：

D O I：

10.1021/ja801436j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A Trojan horse PRINT particle composition was developed that incorporates a reductively labile cross-linker to achieve activated release of doxorubicin in vitro. Particles of discrete size and shape (cube side.. length = 2 mu m) containing 30 wt % of a disulfide-based cross-linker and 2 wt % doxorubicin were synthesized. This PRINT composition was shown to release doxorubicin in response to a reducing environment as measured by flow cytometry and was found to be highly proficient at killing HeLa cells in vitro.

引用

页码：5008 / +

页数：3

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