Updates on bisphosphonates and potential pathobiology of bisphosphonate-induced jaw osteonecrosis

被引：82

作者：

Sarin, J. ^{[1
]}

DeRossi, S. S. ^{[1
]}

Akintoye, S. O. ^{[1
]}

机构：

[1] Univ Penn, Sch Dent Med, Dept Oral Med, Philadelphia, PA 19104 USA

来源：

ORAL DISEASES | 2008年 / 14卷 / 03期

关键词：

bisphosphonates; jaw; osteonecrosis; biology; bone marrow;

D O I：

10.1111/j.1601-0825.2007.01381.x

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Osteonecrosis of the jaws is a major complication associated with long-term use of bisphosphonates. While osteonecrosis can arise from other precipitating conditions, bisphosphonate-induced jaw osteonecrosis (BJON) is highly associated with long-term administration of pamidronate (Aredia (R)) and zoledronic acid (Zometa (R)), which are two intravenous bisphosphonate formulations. The underlying pathogenesis of BJON and its site-specific presentation still remain to be fully elucidated. This review will discuss clinically available bisphosphonates, current opinions, pathogenesis, and management guidelines for bisphosphonate-induced jaw osteonecrosis.

引用

页码：277 / 285

页数：9

共 49 条

[41] EFFECT OF ETHANE-1-HYDROXY-1,1-DIPHOSPHONATE (EHDP) AND DICHLOROMETHYLENE DIPHOSPHONATE (CL2MDP) ON CALCIFICATION AND RESORPTION OF CARTILAGE AND BONE IN TIBIAL EPIPHYSIS AND METAPHYSIS OF RATS [J].

SCHENK, R ;

MERZ, WA ;

MUHLBAUER, R ;

RUSSELL, RGG ;

FLEISCH, H .

CALCIFIED TISSUE RESEARCH, 1973, 11 (03) :196-214

[42]

Stefanik D, 2006, J Dent Res, V85, P430

[43] EFFECT OF INTERMITTENT CYCLICAL ETIDRONATE THERAPY ON BONE MASS AND FRACTURE RATE IN WOMEN WITH POSTMENOPAUSAL OSTEOPOROSIS [J].

STORM, T ;

THAMSBORG, G ;

STEINICHE, T ;

GENANT, HK ;

SORENSEN, OH .

NEW ENGLAND JOURNAL OF MEDICINE, 1990, 322 (18) :1265-1271

[44]

*USFDA, 2005, MEDWATCH SAF INF

[45] Bisphosphonates and osteonecrosis of the jaw:: cause and effect or a post hoc fallacy? [J].

Van den Wyngaert, T. ;

Huizing, M. T. ;

Vermorken, J. B. .

ANNALS OF ONCOLOGY, 2006, 17 (08) :1197-1204

[46] Bisphosphonates inhibit the adhesion of breast cancer cells to bone matrices in vitro [J].

vanderPluijm, G ;

Vloedgraven, H ;

vanBeek, E ;

vanderWeePals, L ;

Lowik, C ;

Papapoulos, S .

JOURNAL OF CLINICAL INVESTIGATION, 1996, 98 (03) :698-705

[47] Bisphosphonates pamidronate and zoledronic acid stimulate osteoprotegerin production by primary human osteoblasts [J].

Viereck, V ;

Emons, G ;

Lauck, V ;

Frosch, KH ;

Blaschke, S ;

Gründker, C ;

Hofbauer, LC .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2002, 291 (03) :680-686

[48] INTERMITTENT CYCLICAL ETIDRONATE TREATMENT OF POSTMENOPAUSAL OSTEOPOROSIS [J].

WATTS, NB ;

HARRIS, ST ;

GENANT, HK ;

WASNICH, RD ;

MILLER, PD ;

JACKSON, RD ;

LICATA, AA ;

ROSS, P ;

WOODSON, GC ;

YANOVER, MJ ;

MYSIW, WJ ;

KOHSE, L ;

RAO, MB ;

STEIGER, P ;

RICHMOND, B ;

CHESNUT, CH .

NEW ENGLAND JOURNAL OF MEDICINE, 1990, 323 (02) :73-79

[49] Systematic review: Bisphosphonates and osteonecrosis of the jaws [J].

Woo, Sook-Bin ;

Hellstein, John W. ;

Kalmar, John R. .

ANNALS OF INTERNAL MEDICINE, 2006, 144 (10) :753-761

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