ECT of major depressed patients in relation to biological and clinical variables: A brief overview

被引:54
作者
Wahlund, B
von Rosen, D
机构
[1] Department of Agricultural Sciences, Biomathematics and Informatics
关键词
ECT; EEG; depression; mechanism; connectivity; review;
D O I
10.1038/sj.npp.1300135
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The knowledge that spontaneous or induced convulsions can improve mental disorders has been present for several centuries, electroconvulsive therapy (ECT) has undergone fundamental changes since its introduction, and in the last 15-20 years there has been a legitimate renewal of interest for this therapy. Today the indications for use of ECT seem well codified, and its technique and practices have evolved considerably. It is now firmly established as an important and effective method of treating certain severe forms of depression. However, still very little is known about the mechanism of ECT. In this paper, first, we will give a short overview as to how far we have got concerning ECT in relation to various clinical and biological variables. Second, we will describe ECT in relation to electroencephalographic (EEG) technique and clinical outcome as well as give some proposals as to how to go on with the data analysis of EEG. In conclusion, the superior effect of ECT compared to other antidepressives in severe depression may depend on neurochemical and neurobiological cascade effects initiated by repeated treatments. Above all, ECT offers a unique experimental opportunity to study how neuromodulation of the major transmitter systems may be involved in brain dynamics and alteration of connectivity.
引用
收藏
页码:S21 / S26
页数:6
相关论文
共 53 条
[11]   Neurotrophins require distinct extracellular signals to promote the survival of CNS neurons in vitro [J].
Franke, B ;
Bayatti, N ;
Engele, J .
EXPERIMENTAL NEUROLOGY, 2000, 165 (01) :125-135
[12]  
GALL C, 1991, EPILEPSY RES, P225
[13]   Mossy fiber sprouting induced by repeated electroconvulsive shock seizures [J].
Gombos, Z ;
Spiller, A ;
Cottrell, GA ;
Racine, RJ ;
Burnham, WM .
BRAIN RESEARCH, 1999, 844 (1-2) :28-33
[14]   Effects of chronic antidepressant drug administration and electroconvulsive shock on locus coeruleus electrophysiologic activity [J].
Grant, MM ;
Weiss, JM .
BIOLOGICAL PSYCHIATRY, 2001, 49 (02) :117-129
[15]   Mechanism underlying the therapeutic effects of electroconvulsive therapy (ECT) on depression [J].
Ishihara, K ;
Sasa, M .
JAPANESE JOURNAL OF PHARMACOLOGY, 1999, 80 (03) :185-189
[16]   Neuropeptide Y in male and female brains of flinders sensitive line, a rat model of depression.: Effects of electroconvulsive stimuli [J].
Jiménez-Vasquez, PA ;
Overstreet, DH ;
Mathé, AA .
JOURNAL OF PSYCHIATRIC RESEARCH, 2000, 34 (06) :405-412
[17]   Electrical stimulation of rat medial prefrontal cortex enhances forebrain serotonin output: Implications for electroconvulsive therapy and transcranial magnetic stimulation in depression [J].
Juckel, G ;
Mendlin, A ;
Jacobs, BL .
NEUROPSYCHOPHARMACOLOGY, 1999, 21 (03) :391-398
[18]   Plasma noradrenaline response to electroconvulsive therapy in depressive illness [J].
Kelly, CB ;
Cooper, SJ .
BRITISH JOURNAL OF PSYCHIATRY, 1997, 171 :182-186
[19]  
LeDoux J. E., 1996, EMOTIONAL BRAIN MYST
[20]   Quantitative EEG during seizures induced by electroconvulsive therapy: Relations to treatment modality and clinical features. II. Topographic analyses [J].
Luber, B ;
Nobler, MS ;
Moeller, JR ;
Katzman, GP ;
Prudic, J ;
Devanand, DP ;
Dichter, GS ;
Sackeim, HA .
JOURNAL OF ECT, 2000, 16 (03) :229-243