Unravelling the complexity of attention-deficit hyperactivity disorder: a behavioural genomic approach

被引：23

作者：

Asherson, P ^{[1
]}

Kuntsi, J ^{[1
]}

Taylor, E ^{[1
]}

机构：

[1] MRC, Inst Psychiat, Social Genet & Dev Psychiat Res Ctr, London SE5 8AF, England

来源：

BRITISH JOURNAL OF PSYCHIATRY | 2005年 / 187卷

基金：

英国惠康基金;

关键词：

D O I：

10.1192/bjp.187.2.103

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

International research has established that there is a strong genetically inherited contribution to attention-deficit hyperactivity disorder (ADHD) and the genetic mechanisms involved are being sought with considerable success. It is now established that certain alleles of the genes coding for the dopamine D-4 receptor and the dopamine transporter occur more frequently in children with ADHD than in healthy controls, and we are finding other DNA changes associated with ADHD. A major challenge for the field now is to clarify how genetic susceptibility is translated into disorder by integrating the fields of quantitative and molecular genetics, neuropsychology and environmental risks.

引用

页码：103 / 105

页数：3

共 17 条

[1] Attention-deficit hyperactivity disorder in the post-genomic era
Asherson, P
[J]. EUROPEAN CHILD & ADOLESCENT PSYCHIATRY, 2004, 13 (Suppl 1) : 50 - 70
[2] CANTWELL DP, 1972, ARCH GEN PSYCHIAT, V27, P414
[3] Neuroscience of attention-deficit/hyperactivity disorder: The search for endophenotypes
Castellanos, FX
Tannock, R
[J]. NATURE REVIEWS NEUROSCIENCE, 2002, 3 (08) : 617 - 628
[4] Attention-deficit/hyperactivity disorder in adults: An overview
Faraone, SV
Biederman, J
Spencer, T
Wilens, T
Seidman, LJ
Mick, E
Doyle, AE
[J]. BIOLOGICAL PSYCHIATRY, 2000, 48 (01) : 9 - 20
[5] Faraone SV, 2000, GENET EPIDEMIOL, V18, P1
[6] Role of dopamine transporter genotype and maternal prenatal smoking in childhood hyperactive-impulsive, inattentive, and oppositional behaviors
Kahn, RS
Khoury, J
Nichols, WC
Lanphear, BP
[J]. JOURNAL OF PEDIATRICS, 2003, 143 (01) : 104 - 110
[7] Kuntsi J, 2005, ATTENTION DEFICIT HYPERACTIVITY DISORDER (ADHD) RESEARCH DEVELOPMENTS, P1
[8] Genetic influences on the stability of attention-deficit/hyperactivity disorder symptoms from early to middle childhood
Kuntsi, J
Rijsdijk, F
Ronald, A
Asherson, P
Plomin, R
[J]. BIOLOGICAL PSYCHIATRY, 2005, 57 (06) : 647 - 654
[9] Psychological mechanisms in hyperactivity: II The role of genetic factors
Kuntsi, J
Stevenson, J
[J]. JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY, 2001, 42 (02) : 211 - 219
[10] Prenatal smoking and early childhood conduct problems - Testing genetic and environmental explanations of the association
Maughan, B
Taylor, A
Caspi, A
Moffitt, TE
[J]. ARCHIVES OF GENERAL PSYCHIATRY, 2004, 61 (08) : 836 - 843

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