How important is the 'quality' of the cytotoxic T lymphocyte (CTL) response in protection against HIV infection?

被引：59

作者：

Rowland-Jones, SL ^{[1
]}

Pinheiro, S

Kaul, R

Hansasuta, P

Gillespie, G

Dong, T

Plummer, FA

Bwayo, JB

Fidler, S

Weber, J

McMichael, A

Appay, V

机构：

[1] John Radcliffe Hosp, Inst Mol Med, MRC, Human Immunol Unit, Oxford OX3 9DS, England

[2] Univ Nairobi, Dept Med Microbiol, Nairobi, Kenya

[3] St Marys Hosp, Imperial Coll Sch Med, Dept Genitourinary Med, London, England

来源：

IMMUNOLOGY LETTERS | 2001年 / 79卷 / 1-2期

基金：

英国医学研究理事会;

关键词：

CTLs; HIV-1; tetramers; perforin; cytokine; CD27;

D O I：

10.1016/S0165-2478(01)00261-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cytotoxic T lymphocyte (CTL) responses have been associated with protection from HIV-1 infection in people with a high degree of exposure to HIV and who show no serological evidence of HIV infection (HEPS, highly exposed persistently seronegative). However, it remains unclear how protective CTL responses could apparently develop in a minority of people, whilst the great majority of HIV-infected people make strong CTL responses yet progress to AIDS and death. In this paper we review the data which supports the hypothesis that the quality of the T-cell response, rather than its magnitude, may be an important factor that merits further investigation. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：15 / 20

页数：6

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