Cell competition and its possible relation to cancer

被引：69

作者：

Baker, Nicholas E. ^{[1
]}

Li, Wei ^{[1
]}

机构：

[1] Yeshiva Univ Albert Einstein Coll Med, Dept Mol Genet, Bronx, NY 10461 USA

来源：

CANCER RESEARCH | 2008年 / 68卷 / 14期

关键词：

D O I：

10.1158/0008-5472.CAN-07-6348

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cell competition can occur when cells of different genotypes share the same developing compartment, with one genotype displacing the other as a result of a proliferative advantage. Studies of cell competition in Drosophila have identified an active process of cell assassination and corpse engulfment, and also roles for Myc and the Warts/Hippo tumor suppressor pathway. Here, we discuss the possible relevance of cell competition to cancer.

引用

页码：5505 / 5507

页数：3

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