Enantiopure building blocks for marine natural products via differentiation of enantiotopic groups

被引：17

作者：

Beil, W

Jones, PG

Nerenz, F

Winterfeldt, E

机构：

[1] Univ Hannover, Inst Organ Chem, D-30167 Hannover, Germany

[2] Med Hsch Hannover, Inst Allgemeine Pharmakol Med, D-30625 Hannover, Germany

[3] Tech Univ Braunschweig, Inst Anorgan & Analyt Chem, D-38106 Braunschweig, Germany

来源：

TETRAHEDRON | 1998年 / 54卷 / 26期

关键词：

D O I：

10.1016/S0040-4020(98)00158-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The group and face-selective cycloaddition of the enantiopure cyclopentadiene 4 to the tyrosine-related spirocylohexadienone 10 provided a high yield of the enantiomerically pure cyclohexadienone 11. Stereoselective transformations at the remaining double bond followed by a thermal retro-process, finally giving rise to the chromophore of the marine agelorin antibioticcs isolated from the sponge Agelas oroides Schmidt. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：7273 / 7292

页数：20

共 21 条

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