Serotonergic response to stress: A protective factor against abnormal dopaminergic reactivity in schizophrenia?

被引：8

作者：

Brunelin, Jerome

D'amato, Thierry

van Os, Jim

Dalery, Jean

Suaud-Chagny, Marie-Francoise

Saoud, Mohamed

机构：

[1] Univ Lyon 1, CH Le Vinatier, Serv Pr Dalery, EA3092, F-69677 Bron, France

[2] Univ Lyon, F-69003 Lyon, France

[3] IFNL, Lyon, France

[4] Maastricht Univ, EURON, S Limburg Mental Hlth Res & Teaching Network, NL-6200 MD Maastricht, Netherlands

[5] Inst Psychiat, Div Psychol Med, London SE5 8AF, England

来源：

EUROPEAN PSYCHIATRY | 2007年 / 22卷 / 06期

关键词：

schizophrenia; vulnerability-stress model; prevention;

D O I：

10.1016/j.eurpsy.2007.01.1219

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

In a double-blind-crossover-study, 10 patients with schizophrenia, 10 of their unaffected siblings and 9 healthy controls randomly received metabolic stressor and placebo. A significant HVA plasma elevation in response to stress was found in siblings whose response was intermediate to that of patients and controls. Only siblings additionally displayed an exaggerated 5HIAA response. (c) 2007 Elsevier Masson SAS. All rights reserved.

引用

页码：362 / 364

页数：3

共 15 条

[1] Striatal amphetamine-induced dopamine release in patients with schizotypal personality disorder studied with single photon emission computed tomography and [123I]iodobenzamide
Abi-Dargham, A
Kegeles, LS
Zea-Ponce, Y
Mawlawi, O
Martinez, D
Mitropoulou, V
O'Flynn, K
Koenigsberg, HW
Van Heertum, R
Cooper, T
Laruelle, M
Siever, LJ
[J]. BIOLOGICAL PSYCHIATRY, 2004, 55 (10) : 1001 - 1006
[2] Amaresan MS, 2005, INDIAN J NEPHROL, V15, P01
[3] HOMOVANILLIC-ACID MEASUREMENT IN CLINICAL RESEARCH - A REVIEW OF METHODOLOGY
AMIN, F
DAVIDSON, M
DAVIS, KL
[J]. SCHIZOPHRENIA BULLETIN, 1992, 18 (01) : 123 - 148
[4] ALPRAZOLAM ATTENUATES METABOLIC STRESS-INDUCED NEUROENDOCRINE AND BEHAVIORAL-EFFECTS IN HUMANS
BREIER, A
DAVIS, OR
BUCHANAN, RW
[J]. PSYCHOPHARMACOLOGY, 1991, 104 (04) : 479 - 484
[5] The schizophrenia prodrome: treatment and high-risk perspectives
Cornblatt, B
Lencz, T
Obuchowski, M
[J]. SCHIZOPHRENIA RESEARCH, 2002, 54 (1-2) : 177 - 186
[6] Effects of acute metabolic stress on the peripheral vasopressinergic system in schizophrenia
Elman, I
Lukas, S
Shoaf, SE
Rott, D
Adler, C
Breier, A
[J]. JOURNAL OF PSYCHOPHARMACOLOGY, 2003, 17 (03) : 317 - 323
[7] GOTTESMAN II, 1989, ARCH GEN PSYCHIAT, V46, P867
[8] ASSESSMENT OF BRAIN DOPAMINE METABOLISM FROM PLASMA HVA AND MHPG DURING DEBRISOQUIN TREATMENT - VALIDATION IN MONKEYS TREATED WITH MPTP
KOPIN, IJ
BANKIEWICZ, KS
HARVEYWHITE, J
[J]. NEUROPSYCHOPHARMACOLOGY, 1988, 1 (02) : 119 - 125
[9] Serotonergic basis of antipsychotic drug effects in schizophrenia
Lieberman, JA
Mailman, RB
Duncan, G
Sikich, L
Chakos, M
Nichols, DE
Kraus, JE
[J]. BIOLOGICAL PSYCHIATRY, 1998, 44 (11) : 1099 - 1117
[10] Abnormal response to metabolic stress in schizophrenia: marker of vulnerability or acquired sensitization?
Marcelis, M
Cavalier, E
Gielen, J
Delespaul, P
Van Os, J
[J]. PSYCHOLOGICAL MEDICINE, 2004, 34 (06) : 1103 - 1111

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