Serotonergic response to stress: A protective factor against abnormal dopaminergic reactivity in schizophrenia?

被引：8

作者：

Brunelin, Jerome

D'amato, Thierry

van Os, Jim

Dalery, Jean

Suaud-Chagny, Marie-Francoise

Saoud, Mohamed

机构：

[1] Univ Lyon 1, CH Le Vinatier, Serv Pr Dalery, EA3092, F-69677 Bron, France

[2] Univ Lyon, F-69003 Lyon, France

[3] IFNL, Lyon, France

[4] Maastricht Univ, EURON, S Limburg Mental Hlth Res & Teaching Network, NL-6200 MD Maastricht, Netherlands

[5] Inst Psychiat, Div Psychol Med, London SE5 8AF, England

来源：

EUROPEAN PSYCHIATRY | 2007年 / 22卷 / 06期

关键词：

schizophrenia; vulnerability-stress model; prevention;

D O I：

10.1016/j.eurpsy.2007.01.1219

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

In a double-blind-crossover-study, 10 patients with schizophrenia, 10 of their unaffected siblings and 9 healthy controls randomly received metabolic stressor and placebo. A significant HVA plasma elevation in response to stress was found in siblings whose response was intermediate to that of patients and controls. Only siblings additionally displayed an exaggerated 5HIAA response. (c) 2007 Elsevier Masson SAS. All rights reserved.

引用

页码：362 / 364

页数：3

共 15 条

[11] Subtle fluctuations in psychotic phenomena as functional states of abnormal dopamine reactivity in individuals at risk
Myin-Germeys, I
Marcelis, M
Krabbendam, L
Delespaul, P
van Os, J
[J]. BIOLOGICAL PSYCHIATRY, 2005, 58 (02) : 105 - 110
[12] Neuropsychological deficit in siblings discordant for schizophrenia
Saoud, M
d'Amato, T
Gutknecht, C
Triboulet, P
Bertaud, JP
Marie-Cardine, M
Daléry, J
Rochet, T
[J]. SCHIZOPHRENIA BULLETIN, 2000, 26 (04) : 893 - 902
[13] SPRING B, 1978, NATURE SCHIZOPHRENIA, P366
[14] The ecogenetics of schizophrenia: a review
van Os, J
Marcelis, M
[J]. SCHIZOPHRENIA RESEARCH, 1998, 32 (02) : 127 - 135
[15] YAMAMOTO BK, 1994, J CLIN PSYCHIAT, V55, P8

← 1 2 →