Chiral chromatographic separation of β-blockers

被引：24

作者：

Agrawal, YK ^{[1
]}

Patel, RN ^{[1
]}

机构：

[1] Nirma Univ Sci & Technol, Inst Pharm, Ahmadabad 382481, Gujarat, India

来源：

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES | 2005年 / 820卷 / 01期

关键词：

chiral stationary phase; XAD-4; beta-blockerx;

D O I：

10.1016/j.jchromb.2005.03.003

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A novel amide based chiral stationary phase m-[(+)-alpha-methyl benzyl carboxamide] XAD-4 has been synthesized by covalently linking R(+)-l-phenylethylamine to chloroformoyl Amberlite XAD-4 under weak alkaline conditions. The synthesized resin has been primarily characterized by m.p., elemental analysis and Fr-IR and C-13 NMR spectra. beta-Blockers viz. atenolol, metoprolol, and propranolol were successfully separated into their enantiomers using a mixture of sodium acetate-acetic acid buffer (pH 4.1):acetonitrile (4:6, v/v) solution using the synthesized resin. Hydrogen bonding and pi-pi interactions are supposed to be the major analyte-chiral stationary phase interactions. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：23 / 31

页数：9

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