Genetic diversity between human metapneumovirus subgroups

被引：213

作者：

Biacchesi, S

Skiadopoulos, MH

Boivin, G

Hanson, CT

Murphy, BR

Collins, PL

Buchholz, UJ

机构：

[1] NIAID, Infect Dis Lab, Bethesda, MD 20892 USA

[2] Ctr Hosp Univ Quebec, St Foy, PQ G1V 4G2, Canada

[3] Univ Laval, St Foy, PQ G1V 4G2, Canada

来源：

VIROLOGY | 2003年 / 315卷 / 01期

关键词：

metapneumovirus; subgroup; genomic sequence;

D O I：

10.1016/S0042-6822(03)00528-2

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Complete consensus nucleotide sequences were determined for human metapneumovirus (HMPV) isolates CAN97-83 and CAN98-75, representing the two proposed genotypes or genetic subgroups of HMPV. The overall level of genome nucleotide sequence identity and aggregate proteome amino acid sequence identity between the two HMPV subgroups were 80 and 90%, respectively, similar to the respective values of 81 and 88% between the two antigenic subgroups of human respiratory syncytial virus (HRSV). The diversity between HMPV subgroups was greatest for the SH and G proteins (59 and 37% identity, respectively), which were even more divergent than their HRSV counterparts (72 and 55% cross-subgroup identity, respectively). It is reasonable to anticipate that the two genetic subgroups of HMPV represent antigenic subgroups approximately comparable to those of HRSV. (C) 2003 Elsevier Inc. All rights reserved.

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页码：1 / 9

页数：9

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